Kidney failure, also known as renal failure, occurs when the kidneys lose their ability to function effectively.

Kidney

The causes of kidney failure can be broadly categorized into acute and chronic, each with its own set of underlying issues.

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Acute Kidney Failure

1. Acute Glomerulonephritis: Inflammation of the kidney’s filtering units (glomeruli) due to infections or autoimmune conditions.

2. Acute Tubular Necrosis (ATN): Damage to the kidney’s tubules, often caused by severe dehydration, toxins (such as certain medications or contrast dyes used in imaging studies), or infections.

3. Obstruction: Blockage in the urinary tract (e.g., kidney stones, tumors, or an enlarged prostate) can prevent urine from leaving the kidneys, leading to acute kidney injury.

4. Severe Infections: Systemic infections like sepsis can lead to a sudden drop in blood pressure and kidney function.

5. Reduced Blood Flow: Conditions that reduce blood flow to the kidneys, such as severe dehydration, blood loss, or heart failure.

6. Medications and Toxins: Certain drugs and toxins can damage the kidneys, including nonsteroidal anti-inflammatory drugs (NSAIDs), some antibiotics, and chemotherapy drugs.

Chronic Kidney Failure

1. Diabetes: High blood sugar levels from diabetes can damage the kidney’s blood vessels and filtration units over time, leading to diabetic nephropathy.

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2. Hypertension: High blood pressure can damage the kidneys’ blood vessels, reducing their ability to filter blood efficiently.

3. Chronic Glomerulonephritis: Long-term inflammation of the glomeruli, often due to autoimmune diseases or chronic infections.

4. Polycystic Kidney Disease: A genetic disorder where fluid-filled cysts grow in the kidneys, impairing their function over time.

5. Chronic Obstructive Uropathy: Prolonged obstruction in the urinary tract, such as from kidney stones or an enlarged prostate, can lead to chronic damage.

6. Recurrent Infections: Frequent infections can cause scarring and impair kidney function over time.

7. Autoimmune Diseases: Conditions like lupus or vasculitis that cause the immune system to attack the kidneys.

8. Long-term Use of Certain Medications: Prolonged use of certain medications, like NSAIDs or some antibiotics, can contribute to chronic kidney damage.

9. Kidney Stones: Repeated kidney stones can lead to kidney damage and eventually chronic kidney failure if not managed properly.

General Risk Factors
1. Family History: A family history of kidney disease can increase the risk of developing chronic kidney failure.

2. Age: Kidney function naturally declines with age, which can make older adults more susceptible.

3. Lifestyle Factors: Poor diet, lack of exercise, and smoking can contribute to conditions like diabetes and hypertension, which are major risk factors for kidney failure.

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Preventive measures include managing chronic conditions like diabetes and hypertension, avoiding nephrotoxic drugs and substances, staying hydrated, and maintaining a healthy lifestyle.

Regular check-ups with a healthcare provider can help catch potential kidney issues early and manage them effectively.

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